Asian females without diabetes are protected from obesity‐related dysregulation of glucose metabolism compared with males
Authors' conclusion
The female sex exerts a protective effect on obesity-driven dysregulation of glucose metabolism in Asian individuals without diabetes.
Study context
- Population
- Asian individuals without diabetes in Singapore
- Participants
- 727 / 952 / 602 / 662 / 415
- Exposure
- Females vs males across BMI categories
- Malesn = 727
- Femalesn = 952
- Normal body weightn = 602reference
- Overweightn = 662
- Obesityn = 415
- Outcome
- Insulin sensitivity (hyperinsulinemic-euglycemic clamp) and insulin secretion (OGTT, intravenous glucose challenge, mathematical modeling)
Main finding
As reported in the abstract
Effect of sex on obesity-driven changes in glucose metabolism
- No sex differences among lean individuals
- Progressive adverse effects of obesity on insulin action and secretion more pronounced in males than females
- Among participants with obesity, females had greater insulin sensitivity, lower insulin secretion and lower fasting insulin concentration than males
Observational data: associations, not effects.
Further findings
- Increase in WHR with increasing BMI more pronounced in males than females
Original publication
Asian females without diabetes are protected from obesity‐related dysregulation of glucose metabolism compared with males. Obesity (Silver Spring). Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →