Circadian misalignment increases 24‐hour acylated ghrelin in chronic shift workers: a randomized crossover trial
Authors' conclusion
These results reveal that circadian misalignment, while carefully controlling for dietary intake, increases acylated ghrelin in chronic shift workers. Further studies should test whether the observed acute effects of circadian misalignment in chronic shift workers contribute to their increased obesity risk in the long term.
Study context
- Population
- Healthy chronic night shift workers
- Participants
- 7 workers
- Comparison
- Circadian misalignment vs circadian alignment
Methodological detailslaboratory protocols
- Laboratory protocols
Primary result
As reported in the abstract
24-hour acylated ghrelin
Increase in 24-hour acylated ghrelin with circadian misalignment (p = 0.009)
≈17%
Further findings
Hunger at breakfast in the night shift
- Higher hunger at breakfast with circadian misalignment (p = 0.04)
- ≈14%
Fasting and postprandial energy expenditure and respiratory exchange ratio
- Not significantly changed by circadian misalignment (all p > 0.32)
24-hour behavioral activity levels
- Higher activity during circadian misalignment (p < 0.0001)
- ≈38%
Sleepiness
- Increased sleepiness during circadian misalignment (p = 0.03)
Original publication
Circadian misalignment increases 24‐hour acylated ghrelin in chronic shift workers: a randomized crossover trial. Obesity (Silver Spring). Published 3 August 2023. doi:10.
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