Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity: A laboratory study
Authors' conclusion
Acute sleep deprivation reduces blood concentrations of the satiety hormone leptin. With increased blood concentrations of ghrelin and adiponectin, such endocrine changes may facilitate weight gain if persisting over extended periods of sleep loss. The observed sex- and weight-specific differences in leptin, ghrelin, and adiponectin call for further investigation.
Study context
- Population
- Adults with healthy weight and obesity; mean age 24.9 years; 20 women; 19 with obesitycrossover
- Participants
- 44 adults
- Comparison
- One night of total sleep deprivation vs one night of sleep
- Primary endpoint
- Fasting blood concentrations of leptin, ghrelin and adiponectin
- Follow-up
- After each night
Primary result
As reported in the abstract
Fasting leptin, ghrelin and adiponectin
| Group | Value | Ghrelin, mean (SE) | Adiponectin, mean (SE) |
|---|---|---|---|
| Sleep deprivation | mean 17.3 (SE 2.6) ng/mL | 839.4 [77.5] pg/mL | 7.5 [0.6] μg/mL |
| Sleep | mean 18.6 (SE 2.8) ng/mL | 741.4 [63.2] pg/mL | 6.8 [0.6] μg/mL |
Value
Sleep deprivationmean 17.3 (SE 2.6) ng/mL
Sleepmean 18.6 (SE 2.8) ng/mL
Ghrelin, mean (SE)
Sleep deprivation839.4 [77.5] pg/mL
Sleep741.4 [63.2] pg/mL
Adiponectin, mean (SE)
Sleep deprivation7.5 [0.6] μg/mL
Sleep6.8 [0.6] μg/mL
- Sleep deprivation vs Sleep: all p < 0.05 — leptin lower; ghrelin and adiponectin higher after sleep deprivation
Further findings
Sex- and weight-specific changes
- Changes in leptin and adiponectin after sleep loss more pronounced among women
- Ghrelin increase stronger among those with obesity
- Adiponectin increase more marked among normal-weight participants
Original publication
Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity: A laboratory study. Obesity (Silver Spring). Published 20 November 2022. doi:10.
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