Cardiovascular risk stratification among individuals with obesity: The Coronary Artery Calcium Consortium
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.05 95% CI 1.49–2.82Authors' conclusion
Among individuals with obesity, including moderate-severe obesity, CAC strongly predicts all-cause, CVD, and CHD mortality and may serve as an effective cardiovascular risk stratification tool to prioritize the allocation of therapies for weight management.
Study context
- Population
- Individuals with BMI ≥ 30 kg/m² and no prior cardiovascular diseases (CVD), coronary artery calcification (CAC) Consortium; mean age 53.3 ± 9.7 years, 67.9% men
- Participants
- 9,334 individuals
- Exposure
- CAC categories vs CAC = 0
- Outcome
- All-cause and cause-specific (CVD, coronary heart disease (CHD)) mortality
- Follow-up
- Mean 10.8 ± 3.0 years
Methodological detailsmultivariable-adjusted Cox proportional hazards and competing-risks regression
- Multivariable-adjusted Cox proportional hazards and competing-risks regression
Main finding
All-cause mortality
Hazard ratio
2.05
95% CI 1.49–2.82
By group
CAC ≥300vs CAC = 0
HR 2.05 (95% CI 1.49–2.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Per 1000 person-years
| Outcome | CAC = 0 | CAC = 1-99 | CAC = 100-299 | CAC ≥300 | Subdistribution HR (95% CI) | |
|---|---|---|---|---|---|---|
| CVD mortality · mean follow-up 10.8 ± 3.0 yearsCAC ≥300vs CAC = 0Adjusted for traditional cardiovascular risk factors | 0.4 | 1.1 | 1.5 | 4.2 | 3.48 (1.81–6.70) | |
| CHD mortality · mean follow-up 10.8 ± 3.0 yearsCAC ≥300vs CAC = 0Adjusted for traditional cardiovascular risk factors | 0.2 | 0.6 | 0.6 | 2.5 | 5.44 (2.02–14.66) | |
| 0.050.21520Subdistribution hazard ratio (log scale) |
Subgroup BMI ≥ 35 kg/m²
- CAC ≥ 300 remained significantly associated with the highest risk
Original publication
Cardiovascular risk stratification among individuals with obesity: The Coronary Artery Calcium Consortium. Obesity (Silver Spring). Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →