Association of gut microbiota and glucose metabolism in children with disparate degrees of adiposity
Authors' conclusion
The gut microbiota could favourably compensate for glucose metabolism in children with obesity. Genus Haemophilus and Bifidobacterium longum may influence glucose tolerance and insulin resistance in children with severe obesity.
Study context
- Population
- Chinese children (9.75 ± 1.92 years) with disparate degrees of adiposity
- Participants
- 89 children
- Exposure
- Normal weight vs mild obesity vs severe obesity
- Normal weightn = 29reference
- Mild obesityn = 27
- Severe obesityn = 33
- Outcome
- Gut microbiota composition (LEfSe) and correlations with glucose metabolism and inflammatory markers
Methodological details16S rDNA-based metagenomics
- 16S rDNA-based metagenomics
Main finding
As reported in the abstract
- Mild obesity: FPG positively correlated with A. indistinctus, A. putredinis, negatively with Ruminococcus gnavus; Lipopolysaccharide-binding protein (LBP) negatively correlated with Clostridium hathewayi and Blautia producta
- Severe obesity: OGTT2HPG negatively correlated with Synergistetes, Pyramidobacter, Veillonella parvula, P. piscolens, positively with B. producta; INS and HOMA-IR negatively correlated with Haemophilus, H. parainfluenzae; LBP negatively correlated with Actinobacteria, Bifidobacterium, Lactobacillus, B. longum (all p < 0.05)
- PICRUSt2: glucose metabolism pathway gluconeogenesis I curtailed in severe obesity
- Mild obesity vs Severe obesity: P < 0.05
- Spearman's correlation analysis
Observational data: associations, not effects.
Original publication
Association of gut microbiota and glucose metabolism in children with disparate degrees of adiposity. Pediatr Obes. Published 27 January 2023. doi:10.
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