LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans
Authors' conclusion
Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.
Study context
- Population
- Females and males with normal weight or overweight/mild obesity; subgroup of 123 received an ad libitum high-protein meal123 in meal subgroup
- Participants
- 327 females
- Comparison
- Normal weight vs overweight/mild obesity (OW/OB); fasting vs after high-protein meal
- Primary endpoint
- Fasting plasma LEAP2 concentration
Primary result
As reported in the abstract
Fasting LEAP2 concentration
- LEAP2 higher in females
- p < 0.001
- Associated with LEAP2 SNP rs765760
- p = 0.012
- Associated with LEAP2 SNP rs803223
- p = 0.019
Further findings
Fasting LEAP2 associations in normal weight
- Direct relation with glycaemia
- P = 0.001
- Direct relation with fullness
- P = 0.003
Fasting LEAP2 associations in OW/OB
- Associated with BMI
- P = 0.018
- Associated with waist circumference
- P = 0.014
- Associated with motor impulsivity
- P = 0.005
- Negative association with reward responsiveness
- P = 0.023
LEAP2 and food intake / postprandial change · after high-protein meal
- LEAP2 inversely associated with food intake
- P = 0.034
- LEAP2 decreased after high-protein meal
- P < 0.001
- Decrease particularly in women
- P = 0.002
Original publication
LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans. Diabetes Obes Metab. Published 14 August 2024. doi:10.
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