Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
Authors' conclusion
The relationship of LEAP2 with energy intake and postprandial insulin increase is influenced by meal size but not weight status.
Study context
- Population
- Men with normal weight or overweight/obesity receiving a recommended-energy breakfast test meal
- Exposure
- Men with normal weight (NW) vs OW/OB; CMC vs PMC
- NWn = 84reference
- OW/OBn = 48
- CMCn = 67reference
- Outcome
- Postprandial LEAP2 concentrations, association with voluntary energy intake and modulation by weight status
Methodological detailstest meal study
- Test meal study
Main finding
As reported in the abstract
Postprandial LEAP2 concentration
- Pre-prandial LEAP2 inversely related to ingested calories, only in PMC, independent of weight status
- p = 0.027
- Postprandial LEAP2 inversely related to ingested calories, only in PMC, independent of weight status
- p = 0.031
Observational data: associations, not effects.
Further findings
Fasting LEAP2 and glycaemia
- Positive association in NW (Beta)
- 0.289 (95% CI 0.058, 0.520), p = 0.015
- No association in OW/OB
Postprandial insulin increase
- Postprandial insulin increase
- P < 0.001
- Insulin increase depended on LEAP2 only in CMC, independent of weight status
- P = 0.017
Original publication
Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men. Diabetes Obes Metab. Published 23 May 2025. doi:10.
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