The Effect of Early Time-Restricted Eating vs Later Time-Restricted Eating on Weight Loss and Metabolic Health
Authors' conclusion
This meta-analysis suggests that people may choose early TRE for more effective weight management and metabolic benefits. Nevertheless, further large-scale RCTs are warranted to verify our findings.
Study context
- Population
- Adults with obesity or overweight; Randomized controlled trials (RCTs) published until October 16, 2022 (PubMed, Embase, Web of Science, Cochrane Library)
- Participants
- 730 adults12 RCTs
- Comparison
- Early time-restricted eating (TRE) vs later TRE
- Outcome
- HOMA-IR and body weight
Pooled result
As reported in the abstract
Early TRE vs Later TREDifference (HOMA-IR) (95% CI)P value
Early TRE more effective in improving IR
−0.44(−0.86 to −0.02)
P < 0.05Early TRE vs Later TREDifference (body weight), kg (95% CI)P value
Early TREvs Later TRE
−0.31(−1.15 to 0.53)
P > 0.05Further pooled results
Glycemic metabolism and blood pressure vs non-TRE
- Early TRE rather than later TRE showed significant benefits in glycemic metabolism and blood pressure vs non-TRE
FPG, blood pressure and lipid profiles, early vs later TRE
- No significant differences between early and later TRE
Original publication
The Effect of Early Time-Restricted Eating vs Later Time-Restricted Eating on Weight Loss and Metabolic Health. J Clin Endocrinol Metab. Published 26 January 2023. doi:10.
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