The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression
Authors' conclusion
By blood gene expression analysis of non-obese individuals, we identified potential gene biomarkers correlating to declining IGI, associated to a pathophysiology of inflammation and metabolic dysregulation.
Study context
- Population
- Non-obese individuals (54 males, 42 females), age 52.5 years in 2008; blood collected in 2008 and 2016
- Participants
- 96 individuals
- Exposure
- Decrease in insulinogenic index (IGI) vs minor change in IGI
- Outcome
- Blood gene expression correlating with declining IGI
Methodological detailsblood gene expression analysis, 8-year follow-up (2008 and 2016), IGI derived from fasting and 30-min post-OGTT insulin and glucose
- Blood gene expression analysis
- 8-year follow-up (2008 and 2016)
- IGI derived from fasting and 30-min post-OGTT insulin and glucose
Main finding
As reported in the abstract
Genes correlating with declining IGI at time 0 (2008), related to response to lipid, carbohydrate and hormone metabolism, response to stress and DNA metabolic processes
77 genes
Observational data: associations, not effects.
Original publication
The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Res Clin Pract. Published 11 January 2024. doi:10.
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