Adipose tissue expression of Notch signaling genes in relation to insulin sensitivity and obesity in humans
Authors' conclusion
Notch signaling pathway may be associated with healthy adipose tissue through regulation of adipogenesis in humans.
Study context
- Population
- Individuals with normal weight, overweight or obesity, with or without metabolic syndrome; SAT biopsy (groups 1, 2), SAT and visceral adipose tissue (VAT) at surgery (group 3)3 study groups
- Participants
- 48 / 28 / 12 / 27 / 8 / 23 / 29
- Exposure
- SAT and VAT Notch gene expression by obesity, metabolic syndrome (MS) and weight loss
- Normal-weightn = 48reference
- Overweightn = 28
- Obesityn = 12
- Overweight/obesity before and after weight lossn = 27
- Without obesityn = 8reference
- Obesity without MSn = 23
- Obesity with MSn = 29
- Outcome
- SAT and VAT expression of Notch genes in relation to insulin sensitivity, obesity and MS
Methodological detailsthree study groups, weight loss intervention (group 2)
- Three study groups
- Weight loss intervention (group 2)
Main finding
As reported in the abstract
Notch gene expression in adipose tissue
- Group 1: SAT DLL1, NOTCH2, NOTCH4 and HEY1 lower in obesity vs normal weight
- Group 2: weight loss increased DLL1, JAG1, NOTCH2, NOTCH4 and HES1
- Group 3: both obesity groups had lower SAT and VAT JAG1, NOTCH2, NOTCH4 and HEY1
- Positive correlations between Notch genes and adipogenic genes in all study groups
Observational data: associations, not effects.
Original publication
Adipose tissue expression of Notch signaling genes in relation to insulin sensitivity and obesity in humans. Diabetes Res Clin Pract. Published 22 February 2026. doi:10.
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