The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children
Authors' conclusion
LDAH seems to have a role in AT inflammation and the development of obesity in children.
Study context
- Population
- Children aged 0–18 years with subcutaneous adipose tissue (AT) samples (120 girls, 176 boys; BMI SDS −2.7 to 4.3)
- Participants
- 296 children
- Exposure
- Lipid droplet-associated hydrolase (LDAH) variant rs13385191 minor allele carriers vs non-carriers; LDAH expression levels
- Outcome
- AT LDAH expression and BMI SDS by rs13385191 genotype
Methodological detailsin vitro adipogenesis experiments in SGBS preadipocytes
- In vitro adipogenesis experiments in SGBS preadipocytes
Main finding
As reported in the abstract
Negative correlation between LDAH and AT macrophage infiltration, controlled for age
R = −0.132
p = 0.039
Observational data: associations, not effects.
Further findings
- LDAH expression increased during SGBS adipocyte differentiation; knockdown did not alter differentiation
- TNFα significantly reduced LDAH expression in SGBS cells (p = 0.009)
Original publication
The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children. Obesity (Silver Spring). Published 28 May 2026. doi:10.
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