Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation
Authors' conclusion
These results suggest that CLDN1 is a novel marker induced in obesity and differentially expressed in T lymphocytes infiltrated in human vWAT as compared with sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis, and alter homeostasis and promote metabolic disease in obesity.
Study context
- Population
- Human visceral and subcutaneous white adipose tissue samples from individuals with and without obesity
- Participants
- 11 / 13 / 14
- Comparison
- T lymphocytes from vWAT vs sWAT; whole WAT from individuals with vs without obesity
- Cohort 1n = 11
- Obesityn = 13
- Without obesityn = 14reference
- Outcome
- T-lymphocyte gene expression in vWAT vs sWAT and whole WAT
Methodological detailstranscriptomic analysis (Clariom D), two cohorts
- Transcriptomic analysis (Clariom D)
- Two cohorts
Main finding
As reported in the abstract
- Transcriptional differences between T lymphocytes from sWAT vs vWAT
- CLDN1 expression dramatically induced in vWAT T cells relative to sWAT T cells in patients with obesity
- CLDN1 also induced in obesity in vWAT; expression correlates with genes involved in inflammation, fibrosis and adipogenesis
Original publication
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation. Eur J Endocrinol. Published 20 February 2024. doi:10.
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