Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue
Authors' conclusion
The present findings demonstrate that in vitro mitochondrial respiration and in vivo oxygen fractional extraction are less in upper compared to lower body differentiated hMADS and AT, respectively, in postmenopausal women.
Study context
- Population
- Postmenopausal women with normal weight or obesity, University of Birmingham (Birmingham)/Queen Elizabeth Hospital Birmingham, UK
- Participants
- 23 women
- Exposure
- Abdominal vs femoral differentiated hMADS and subcutaneous adipose tissue (AT)
- Outcome
- Mitochondrial respiration in abdominal vs femoral differentiated hMADS
Main finding
As reported in the abstract
Mitochondrial oxygen consumption rates in differentiated hMADS
- Lower basal and maximal uncoupled mitochondrial oxygen consumption rates in abdominal vs femoral hMADS
Observational data: associations, not effects.
Further findings
In vivo fractional oxygen extraction and carbon dioxide release across AT
- Lower across abdominal than femoral AT
- Subgroup of the same individuals
Oxidative phosphorylation (OXPHOS) protein expression and mitochondrial DNA (mtDNA) content
- Did not significantly differ between abdominal and femoral differentiated hMADS and AT
Original publication
Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue. J Clin Endocrinol Metab. Published 20 February 2024. doi:10.
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