Lipid‐associated macrophages are more abundant in subcutaneous than visceral adipose tissue in patients with obesity
Authors' conclusion
This study characterizes for the first time the macrophage biomarker signature in human VAT- and SAT-infiltrated CD11b+ myeloid cells from individuals with severe obesity. Further studies are required to elucidate their potential role and specific function in the immunometabolism of individuals with obesity.
Study context
- Population
- Individuals with severe obesity
- Comparison
- Subcutaneous adipose tissue (SAT)- vs visceral adipose tissue (VAT)-infiltrated CD11b+ myeloid cells
- Outcome
- Transcriptomic profile of adipose tissue-infiltrated CD11b+ myeloid cells
Main finding
As reported in the abstract
- Gene expression in white adipose tissue-infiltrated CD11b+ myeloid cells was depot-dependent
- Lipid-associated macrophage biomarkers (TREM2, CD9, GPNMB, CD68) higher in SAT than VAT
- VAT cells overexpressed perivascular M2-like adipose tissue macrophage signature genes (LYVE1, TIMD4, MRC1)
- No classical M1/M2 polarization in VAT vs SAT
- CD248, a lipid sensor associated with insulin resistance, overexpressed in SAT vs VAT
Original publication
Lipid‐associated macrophages are more abundant in subcutaneous than visceral adipose tissue in patients with obesity. Obesity (Silver Spring). Published 29 June 2025. doi:10.
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