The miR-200 family in the context of obesity and type 2 diabetes
Authors' conclusion
These results highlight the potential of miR-200 family members as biomarkers and therapeutic targets in metabolic disease.
Study context
- Population
- Individuals with different metabolic statuses; visceral white adipose tissue (vWAT) samples
- Participants
- 94 individuals
- Exposure
- miR-200 family expression in vWAT across metabolic status groups
- noOB-noT2Dn = 19reference
- OB-noT2Dn = 45
- OB-T2Dn = 30
- Outcome
- Expression patterns of miR-200 family members in vWAT
Main finding
As reported in the abstract
Differential expression of miR-200 family members across groups
- hsa-miR-200b-3p upregulated only in OB-noT2D vs noOB-noT2D
- hsa-miR-200c-3p and hsa-miR-141-3p significantly upregulated in both obesity groups vs normal weight
- noOB-noT2D vs OB-noT2D: P = 0.010
- noOB-noT2D vs OB-noT2D: P = 0.002
- noOB-noT2D vs OB-noT2D: P = 0.004
Observational data: associations, not effects.
Further findings
Correlation of BMI with miRNA expression
- Positive correlations between BMI and hsa-miR-200c-3p, hsa-miR-141-3p and hsa-miR-429 expression
Expression by chromosomal location or functional classification
- Distinct expression patterns when microRNAs (miRNAs) grouped by chromosomal location or functional classification
Functional enrichment
- Enriched pathways associated with insulin signaling, inflammation and immune response
Original publication
The miR-200 family in the context of obesity and type 2 diabetes. Diabetes Res Clin Pract. Published 21 September 2025. doi:10.
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