Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity
Authors' conclusion
This is the first study unveiling distinct miRNA expression profiles in paired samples of visceral adipose tissue and skeletal muscle in humans. The identification of obesity-specific miRNAs in these tissues opens up promising avenues for research into potential biomarkers for obesity diagnosis and treatment.
Study context
- Population
- People with obesity (50% with T2D) undergoing bariatric surgery, and controls; paired skeletal muscle and visceral adipose tissue samples
- Participants
- 10 vs 38
- Comparison
- Visceral adipose tissue vs skeletal muscle miRNA expression in people with obesity undergoing bariatric surgery
- Controlsn = 10reference
- People with obesityn = 38
- Outcome
- Differential miRNA expression profile between visceral white adipose tissue and skeletal muscle
Methodological detailspaired tissue samples, Next-Generation Sequencing with RT-PCR validation
- Paired tissue samples
- Next-Generation Sequencing with RT-PCR validation
Main finding
As reported in the abstract
miRNA expression in visceral adipose tissue vs skeletal muscle
miRNAs with similar expression in both tissues
≈69%
miRNAs preferentially expressed in visceral adipose tissue
55
miRNAs preferentially expressed in skeletal muscle
53
Further findings
Differences by presence of T2D
- T2D-related differences observed solely in expression of miR-1-3p and miR-206 in visceral adipose tissue
Original publication
Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity. Int J Obes (Lond). Published 19 November 2024. doi:10.
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