Impact of Tirzepatide on diet-related quality of life and treatment satisfaction in people with type 2 diabetes mellitus: a retrospective cross-sectional study
Authors' conclusion
Despite TZP's appetite-suppressing effects, diet-related QoL, particularly the "perceived merits of dietary therapy", significantly increased with treatment, serving as an independent and substantial contributor to patient satisfaction, comparable to the impact of body weight reduction.
Study context
- Population
- People with T2D treated with tirzepatide
- Participants
- 95 people
- Exposure
- Before vs after Tirzepatide (TZP) treatment
- TZPn = 95
- Outcome
- Diet-related QoL (DDRQOL-R-9) and its influence on treatment satisfaction
Methodological detailsretrospective observational, before-after comparison
- Retrospective observational
- Before-after comparison
Main finding
As reported in the abstract
Median diet-related quality of life (QoL) "perceived merits of dietary therapy" increased with TZP (before to after)
58.3 [IQR 50.0, 75.0] to 67.7 [50.0, 83.3]
p < 0.01
Independent predictor of DTSQs scores post-TZP: changes in BMI
standardized β = - 0.21
p = 0.030
Independent predictor of DTSQs scores post-TZP: changes in diet-related QoL "perceived merits of dietary therapy"
β = 0.23
p = 0.019
Observational data: associations, not effects.
Further findings
HbA1c
Body weight
HbA1c
- Significant reduction with TZP
Body weight
- Significant reduction with TZP
Independent predictors of DTSQs scores post-TZP (multiple regression)
- Change in BMI, standardized β
- - 0.21 (p = 0.030)
- Change in diet-related QoL "perceived merits of dietary therapy", β
- 0.23 (p = 0.019)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →