Association of Physical Activity With All‐Cause and Cardiovascular Disease (CVD) Mortality Across Metabolic and Obesity Phenotypes
Authors' conclusion
Metabolic-obesity phenotypes were associated with differential mortality risk, and higher physical activity was associated with lower all-cause and CVD mortality across phenotypes.
Study context
- Population
- Adults from the Korean National Health Insurance Service health screening cohort (2009–2012); metabolically unhealthy = ≥ 2 modified NCEP-ATP III abnormalities; obesity = BMI ≥ 25 kg/m² (WHO Asia-Pacific)
- Participants
- 442,666 adults
- Exposure
- Metabolic-obesity phenotypes and physical activity levels
- Outcome
- All-cause mortality (and CVD mortality)
Methodological detailsmultivariable Cox proportional hazards models
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
All-cause mortality
Each group vs MHLHazard ratio (95% CI)
MUHL
1.23(1.19–1.26)
MUHO
0.97(0.94–1.01)
MHO
0.85(0.81–0.89)
Observational data: associations, not effects.
Further findings
- Higher physical activity consistently associated with lower all-cause and CVD mortality in a dose-response manner
- Joint analyses: progressively lower mortality across all metabolic-obesity phenotypes with increasing activity
Original publication
Association of Physical Activity With All‐Cause and CVD Mortality Across Metabolic and Obesity Phenotypes. Diabetes Obes Metab. Published 28 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →