Prediabetes and Type 2 Diabetes in Youth following Premature Adrenarche
Authors' conclusion
Compared with national estimates, we observed youth with PA demonstrated higher frequency of dysglycemia and obesity. While prior studies have shown increased insulin resistance in PA compared to all youth with obesity, this study is the first to demonstrate higher rates of subsequent youth-onset T2DM in this population. These findings support close longitudinal monitoring for dysglycemia in children with PA.
Study context
- Population
- Youth diagnosed with benign premature adrenarche (PA), 2011–2022; 82% overweight or obese at PA diagnosis90 with follow-up hemoglobin A1c (HbA1c)
- Participants
- 229 participants
- Exposure
- Males vs Females
- Malesn = 60
- Femalesn = 169
- Outcome
- Subsequent youth-onset PreDM or T2D
Methodological detailsretrospective chart review
- Retrospective chart review
Main finding
As reported in the abstract
PreDM, males and females
38%
T2D, males
8%
T2D, females
6%
Overall dysglycemia frequency
44%
Observational data: associations, not effects.
Further findings
Males: non-Hispanic Black race/ethnicity, PreDM vs normal HbA1c
- Males with PreDM more likely non-Hispanic Black vs normal HbA1c
- P = 0.31
Females: height, weight and BMI at initial PA evaluation, PreDM vs normal HbA1c
- Higher in those who later developed PreDM vs normal HbA1c
- all p < 0.01
Original publication
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