Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging
Authors' conclusion
Disruptions in rhythmic metabolites are implicated in Type 2 diabetes pathophysiology through specific metabolic pathways, highlighting the potential for biomarkers to support circadian-based prevention strategies.
Study context
- Population
- Community-dwelling adults aged 45–85 years (49.1% male), Canadian Longitudinal Study on Aging, with baseline (2012–2015) serum metabolomics data
- Participants
- 9,992 adults
- Outcome
- Incident T2D, assessed by diabetes medication use and HbA1c
- Follow-up
- 3-year follow-up
Methodological detailslongitudinal, untargeted metabolomics, multivariable binomial regression, pathway and network analyses
- Longitudinal
- Untargeted metabolomics
- Multivariable binomial regression
- Pathway and network analyses
Main finding
As reported in the abstract
Rhythmic metabolites associated with incident T2D risk
- Rhythmic metabolites associated with T2D risk, incl. a subset overlapping with genetic predisposition to chronotype
- 20
Observational data: associations, not effects.
Further findings
Mendelian randomisation: causal associations with T2D risk
- Higher mannose, valine, isoleucine, threonine and sphingomyelin (d18:0/18:0, d19:0/17:0) causally associated with higher T2D risk
- Creatine, glycine, 1-linoleoyl-GPC (18:2), 1-palmitoyl-2-oleoyl-GPE, 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) and 1-stearoyl-2-oleoyl-GPE (18:0/18:1) protective
Original publication
Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging. Diabetes Obes Metab. Published 8 March 2026. doi:10.
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