Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease
Authors' conclusion
This study reveals a panel of plasma metabolites linked to the consumption of total and specific types of olive oil. The metabolite profiles of total olive oil consumption and extra virgin olive oil were associated with a decreased risk of incident CVD in a high cardiovascular-risk Mediterranean population, though no associations were observed with T2D incidence.
Study context
- Population
- Participants at high cardiovascular risk from the PREDIMED trial with baseline metabolomics data1,522 validation sample
- Participants
- 1,837 participants
- Primary endpoint
- Plasma metabolites related to total and specific types of olive oil consumption, and associations of multi-metabolite profiles with incident T2D and CVD
Methodological detailscross-sectional discovery with prospective cohort analysis, elastic net regression, 10-fold cross-validation, internal validation sample, multivariable Cox regression
- Cross-sectional discovery with prospective cohort analysis
- Elastic net regression
- 10-fold cross-validation
- Internal validation sample
- Multivariable Cox regression
Primary result
As reported in the abstract
Metabolomic signatures of olive oil consumption
- Total olive oil signature: metabolites
- 74
- VOO signature: metabolites
- 78
- COO signature: metabolites
- 17
- 10-CV Pearson correlation, total olive oil food-frequency questionnaires (FFQ) vs multi-metabolite profile, discovery sample
- 0.40 (95% CI 0.37, 0.44)
- 10-CV Pearson correlation, total olive oil FFQ vs multi-metabolite profile, validation sample
- 0.27 (95% CI 0.22, 0.31)
Further findings
Incident cardiovascular disease (CVD) per 1SD of baseline metabolite profile
- Total olive oil profile, HR per 1SD
- 0.79 (95% CI 0.67, 0.92)
- Extra virgin olive oil profile, HR per 1SD
- 0.70 (95% CI 0.59, 0.83)
- Adjusted for confounders
Incident T2D
- No significant associations between metabolite profiles and T2D incidence
Original publication
Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease. Cardiovasc Diabetol. Published 13 December 2023. doi:10.
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