Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial
Authors' conclusion
In this exploratory, hypothesis-generating secondary analysis, long-term consumption of OA-enriched olive oil was associated with attenuated kidney function decline in patients with T2DM, an effect limited to those with baseline mildly impaired eGFR. These changes were associated with modulation of AGE-related pathways and reduced oxidative stress.
Study context
- Population
- Patients with T2DM
- Participants
- 97 patients
- Comparison
- Oleanolic acid (OA)-enriched olive oil vs control olive oil
- Primary endpoint
- Kidney function decline: eGFR and uACR
- Follow-up
- 12 months
Methodological detailsprespecified, exploratory, Trial powered for glycemic control rather than renal outcomes
- Prespecified
- Exploratory
- Trial powered for glycemic control rather than renal outcomes
Primary result
As reported in the abstract
eGFR decline
- OA-enriched olive oil attenuated estimated glomerular filtration rate (eGFR) decline vs control, restricted to participants with mildly impaired baseline eGFR (60-90 mL/min/1.73 m²)
- No significant interaction among participants with normal baseline eGFR
- OA-enriched oil prevented the rise in urinary albumin-to-creatinine ratio (uACR) observed with control oil
- OA-enriched olive oil vs Control olive oil: time × group interaction p = 0.010
- Exploratory, hypothesis-generating
Further findings
AGE metabolism
- OA reduced AR concentration and increased GloxI activity, lowering circulating MG; CML unchanged
Oxidative stress markers
- OA-enriched oil reduced ROS and MDA; MDA increased with control oil
Original publication
Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial. Diabetes Obes Metab. Published 17 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →