Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial
Authors' conclusion
Dietary intervention trials should quantify actual dietary adherence throughout the trial period to enhance the benefits and to assist results interpretation. A rapid dietary assessment tool, yearly repeated as a screener, was able to capture a strong inverse linear relationship between Mediterranean diet and type 2 diabetes.
Study context
- Population
- Men and women at high cardiovascular risk, initially free of diabetes, randomized to low-fat diet, Mediterranean diet + extra virgin olive oil or Mediterranean diet + mixed nuts; Spainfree of diabetes · randomized to low-fat diet 1,147 · or Mediterranean diet + mixed nuts 1,240
- Participants
- 3,541 men
- Comparison
- Categories of yearly attained adherence to Mediterranean diet
- Primary endpoint
- New-onset T2D
Methodological detailstime-varying Cox models, yearly repeated measures of dietary adherence
- Time-varying Cox models
- Yearly repeated measures of dietary adherence
Primary result
As reported in the abstract
New-onset T2D by attained Mediterranean diet adherence (MEDAS score, cumulative average)
Multivariable-adjusted HR (95% CI)P value
Per + 2 points in Mediterranean Diet Adherence Screener
0.80(0.70–0.92)
linear trend p = .00112-14 points vs < 8 pointshighestvs lowest adherence
0.46(0.25–0.83)
Further findings
Plasma metabolomic signature of MEDAS (67 metabolites), age- and sex-adjusted
- Supported the results
- Subset of 889 participants
Original publication
Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial. Cardiovasc Diabetol. Published 29 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →