Combined associations of visceral adipose tissue and adherence to a Mediterranean lifestyle with T2D and diabetic microvascular complications among individuals with prediabetes
Authors' conclusion
High adherence to MEDLIFE reduced T2D and MDC risk in individuals with prediabetes, while high VAT mass increases it, but MEDLIFE adherence may offset VAT's risk partly. The Mediterranean lifestyle's adaptability to diverse populations suggests promise for preventing T2D.
Study context
- Population
- Individuals with prediabetes, UK Biobank
- Participants
- 11,267 individuals
- Exposure
- Quartiles of Mediterranean lifestyle (MEDLIFE) adherence and of visceral adipose tissue (VAT) mass
- Outcome
- Incident T2D and diabetic microvascular complications (DMC)
- Follow-up
- Median 13.77 years
Methodological detailsUK Biobank, Cox proportional-hazards regression, adjusted for potential confounding factors
- UK Biobank
- Cox proportional-hazards regression
- Adjusted for potential confounding factors
Main finding
As reported in the abstract
Hazard ratio (95% CI)
MEDLIFE highest quartilevs MEDLIFE lowest quartileincident T2D
0.84(0.71–0.98)
MEDLIFE highest quartilevs MEDLIFE lowest quartileincident DMC
0.69(0.56–0.86)
VAT highest quartilevs VAT lowest quartileincident T2D
5.95(4.72–7.49)
VAT highest quartilevs VAT lowest quartileincident any DMC
1.79(1.36–2.35)
- Incident T2D cases
- 1408
- Cases of any diabetic microvascular complications (DMC)
- 714
- Inverse dose-response between MEDLIFE and T2D/DMC; dose-response between VAT and all outcomes
- P for trend < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Combined VAT and MEDLIFE categories, incident T2DLowest VAT and highest MEDLIFEvs Lowest MEDLIFE quartile and highest VAT quartile | 0.12 (0.08–0.19) | |
| 0.050.21520Hazard ratio (log scale) |
Combined VAT and MEDLIFE categories, incident T2D
- High MEDLIFE linked to reduced T2D risk across all VAT categories, except highest VAT quartile; similar trends for DMC
Restricted cubic spline analysis
- Nearly linear dose-response pattern across all associations
Original publication
Combined associations of visceral adipose tissue and adherence to a Mediterranean lifestyle with T2D and diabetic microvascular complications among individuals with prediabetes. Cardiovasc Diabetol. Published 12 June 2024. doi:10.
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