Cardiorespiratory Fitness, Body Composition, Diabetes, and Longevity: A 2-Sample Mendelian Randomization Study
Authors' conclusion
Cardiorespiratory fitness can be improved by favorable body composition, physical activity, and performance enhancers. Despite being a strong predictor of mortality, VO2max is not causally associated with T2D or longevity.
Study context
- Population
- Publicly available summary statistics from the largest GWAS; VO2max estimated from a submaximal cycle ramp test (N ≈ 70,000), scaled to total body weight and in additional analyses to fat-free mass
- Comparison
- Genetically predicted body composition, physical activity, diabetes and performance enhancers vs VO2max; VO2max vs T2D and longevity
- Outcome
- VO2max (per 1 SD increase in genetically predicted exposure)
Methodological detailsmultivariable Mendelian randomization (MR)
- Multivariable MR
Main finding
As reported in the abstract
Body fat percentage → VO2max: β
−0.36
95% CI −0.40, −0.32P = 6 × 10-77
Appendicular lean mass → VO2max: β
0.10
95% CI 0.08 to 0.13P < .01
Physical activity → VO2max: β
0.29
95% CI 0.07 to 0.52P < .01
Further findings
Multivariable MR (MVMR) independent causal effects
- Independent causal effects of body fat percentage, appendicular lean mass, physical activity and hematocrit on VO2max
- Independent causal effects of body fat percentage and T2D on longevity
Genetically predicted VO2max as exposure
- Genetically predicted VO2max showed no associations
Original publication
Cardiorespiratory Fitness, Body Composition, Diabetes, and Longevity: A 2-Sample Mendelian Randomization Study. J Clin Endocrinol Metab. Published 12 June 2024. doi:10.
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