Association between a mediterranean lifestyle and Type 2 diabetes incidence: a prospective UK biobank study
Authors' conclusion
Higher adherence to the MEDLIFE index was associated with lower risk of type 2 diabetes in the UK Biobank. A Mediterranean-type lifestyle, culturally adapted to non-Mediterranean populations, could help prevent diabetes.
Study context
- Population
- Adults aged 40–69 years free of CVD and T2D, UK Biobank cohort, followed from 2009 to 2010 to 2021; Mediterranean lifestyle assessed by the 25-item MEDLIFE index2,724 T2D cases
- Participants
- 112,493 adults
- Exposure
- Increasing quartiles of MEDLIFE adherence vs first quartile
- Outcome
- T2D incidence (from clinical records)
- Follow-up
- Median 9.4 years
Methodological detailspopulation-based, UK Biobank, Cox proportional-hazards regression adjusted for main potential confounders
- Population-based
- UK Biobank
- Cox proportional-hazards regression adjusted for main potential confounders
Main finding
As reported in the abstract
T2D incidence
Hazard ratio (95% CI)P value
Q2vs Q1
0.90(0.82–0.99)
Q3vs Q1
0.80(0.72–0.89)
Q4vs Q1p-trend across quartiles
0.70(0.62–0.79)
P < 0.001for trendObservational data: associations, not effects.
Further findings
- All three blocks of MEDLIFE were independently associated with lower risk of diabetes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between a mediterranean lifestyle and Type 2 diabetes incidence: a prospective UK biobank study. Cardiovasc Diabetol. Published 4 October 2023. doi:10.
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