Insulin resistance assessed by estimated glucose disposal rate and risk of atherosclerotic cardiovascular diseases incidence: the multi-ethnic study of atherosclerosis
Authors' conclusion
eGDR level was negatively associated with incident ASCVD risk in a linear fashion among the general population. Our findings may contribute to preventive measures by improving ASCVD risk assessment.
Study context
- Population
- Participants of the Multi-Ethnic Study of Atherosclerosis; mean age 63.6 ± 10.1 years, 52.5% women
- Participants
- 6,026 participants
- Exposure
- Estimated glucose disposal rate (eGDR) quartiles Q2–Q4 vs lowest quartile
- Outcome
- Incident ASCVD
- Follow-up
- Median 14.1 years
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Q2vs Q1
0.87(0.68–1.10)
Q3vs Q1
0.63(0.47–0.84)
Q4vs Q1
0.43(0.30–0.64)
- Per 1 SD increase in eGDR: Atherosclerotic cardiovascular diseases (ASCVD) risk reduction
- HR 0.70 30% (95% CI 0.60-0.80)
Observational data: associations, not effects.
Further findings
Incident ASCVD events in cohort · median follow-up 14.1 years
- Developed ASCVD
- 565 (9.4%)
- MI
- 256 (4.2%)
- Stroke
- 234 (3.9%)
- Fatal coronary heart disease
- 358 (5.9%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Insulin resistance assessed by estimated glucose disposal rate and risk of atherosclerotic cardiovascular diseases incidence: the multi-ethnic study of atherosclerosis. Cardiovasc Diabetol. Published 28 September 2024. doi:10.
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