Estimated glucose disposal rate outperforms inflammation surrogate markers in predicting cardiometabolic multimorbidity among middle-aged and older adults
Main finding · Incident cardiometabolic multimorbidityResult — go to the resultHazard ratio 2.07 95% CI 1.80–2.38Authors' conclusion
Among middle-aged and older adults, eGDR is significantly associated with incident cardiometabolic multimorbidity regardless of inflammation status. Low eGDR demonstrates superior discriminative ability compared to hs-CRP. These findings suggest that eGDR may serve as a more comprehensive biomarker for cardiometabolic risk stratification by capturing insulin resistance and metabolic dysfunction.
Study context
- Population
- Participants aged ≥45 years from China Health and Retirement Longitudinal Study (CHARLS) with complete baseline data
- Participants
- 7,589 participants
- Exposure
- Lowest vs highest estimated glucose disposal rate (eGDR) quartile; eGDR vs hs-CRP for prediction
- Outcome
- Incident cardiometabolic multimorbidity (co-occurrence of ≥2 of diabetes, heart disease, stroke)
- Follow-up
- 9-year follow-up
Main finding
Incident cardiometabolic multimorbidity
Hazard ratio
2.07
95% CI 1.80–2.38
As reported in the abstract
- Participants developing cardiometabolic multimorbidity
- 2,263
Observational data: associations, not effects.
Further findings
Joint association: low eGDR by inflammation status
- Low eGDR with low inflammation, HR
- 1.52 (95% CI 1.33-1.74)
- Low eGDR with high inflammation, HR
- 1.80 (95% CI 1.58-2.04)
Concordance index (C-index) of basic model plus marker
- C-index with eGDR
- 0.676
- C-index with hs-CRP
- 0.643
- eGDR vs hs-CRP C-index
- P < 0.001
Original publication
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