Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults
Authors' conclusion
Cumulative eGDR and eGDR change were independently associated with increased risk of cardiometabolic multimorbidity in middle-aged and older adults.
Study context
- Population
- Middle-aged and older adults from China Health and Retirement Longitudinal Study (CHARLS) free of CVD and diabetes at baseline
- Participants
- 4,059 participants
- Exposure
- Cumulative estimated glucose disposal rate (eGDR) quartiles and eGDR change groups
- Outcome
- Incident cardiometabolic multimorbidity
- Follow-up
- Median 9.0 years
Methodological detailsK-means clustering of eGDR change, Cox proportional hazards regression
- K-means clustering of eGDR change
- Cox proportional hazards regression
Main finding
As reported in the abstract
Cardiometabolic multimorbidity
Hazard ratio (95% CI)P value
Lowest quartile of cumulative eGDRvs Highest quartile of cumulative eGDRadjusted for potential confounders
1.67(1.34–2.08)
P < 0.001Moderate-lowvs Consistent high
1.64(1.30–2.06)
P < 0.001Consistent lowvs Consistent high
1.62(1.32–1.99)
P < 0.001Consistent moderatevs Consistent high
1.26(1.04–1.53)
P = 0.017- Developed cardiometabolic multimorbidity
- 843 (20.8%)
Observational data: associations, not effects.
Original publication
Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults. Cardiovasc Diabetol. Published 27 April 2026. doi:10.
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