Association of Metabolic Vulnerability Index With Incident Type 2 Diabetes in General Population and All‐Cause Mortality in Patients With Diabetes: A Cohort Study Based on UK Biobank
Authors' conclusion
This study highlights the independent association between MVX and T2DM outcomes as well as diabetes-related mortality.
Study context
- Population
- UK Biobank participants (native UK residents recruited 2006–2010): general population without baseline diabetes (incident T2D analysis) and baseline diabetes cohort (all-cause mortality analysis)34,735 in diabetes cohort
- Participants
- 453,209 participants
- Exposure
- Per 1-SD increase in MVX; highest vs lowest MVX quartile
- Outcome
- Incident T2D in the general population; all-cause mortality in patients with diabetes
Methodological detailspopulation-based, two independent analyses, Cox proportional hazards models, subgroup and sensitivity analyses
- Population-based
- Two independent analyses
- Cox proportional hazards models
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
Incident T2D
Hazard ratio (95% CI)P value
Per 1-SD increase in MVX
1.14(1.11–1.16)
P < 0.001Q4vs Q1
1.32(1.24–1.39)
P = 0.004Observational data: associations, not effects.
Further findings
Incident T2D per 1-SD increase in MVX, normal BMI subgroup
- HR per 1-SD increase in MVX, normal BMI
- 1.24 (95% CI 1.16-1.32), p < 0.001
Incident T2D per 1-SD increase in MVX, females
- HR per 1-SD increase in MVX, females
- 1.17 (95% CI 1.14-1.20), p < 0.001
Incident T2D per 1-SD increase in MVX, aged < 60 years
- HR per 1-SD increase in MVX, aged < 60 years
- 1.18 (95% CI 1.14-1.22), p < 0.001
All-cause mortality in patients with diabetes, by diabetes type (subgroup)
- HR per 1-SD increase in MVX, T1DM
- 1.18 (95% CI 1.07-1.30), p < 0.001
- HR per 1-SD increase in MVX, T2DM
- 1.07 (95% CI 1.04-1.10), p < 0.001
All-cause mortality in patients with diabetes
- HR per 1-SD increase in MVX
- 1.10 (95% CI 1.07-1.13), p < 0.001
Cardiovascular disease (CVD) mortality in patients with diabetes
- HR per 1-SD increase in MVX
- 1.16 (95% CI 1.06-1.26), p < 0.001
Original publication
Association of Metabolic Vulnerability Index With Incident Type 2 Diabetes in General Population and All‐Cause Mortality in Patients With Diabetes: A Cohort Study Based on UK Biobank. Diabetes Obes Metab. Published 27 April 2026. doi:10.
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