Higher dietary magnesium intake and lower risks of all‐cause, cardiovascular and kidney disease mortality in diabetes participants: A large cross‐population cohort study
Authors' conclusion
Higher dietary magnesium intake was consistently associated with reduced risks of all-cause, CVD and KD mortality in US adults with DM and with lower all-cause and CVD mortality in UK adults with DM. These findings highlight the potential prognostic benefit of dietary magnesium intake in DM management.
Study context
- Population
- Adults with diabetes mellitus (DM) from the US NHANES (6004) and the UK Biobank (10,130)two cohorts
- Exposure
- Highest vs lowest quartile of dietary magnesium intake
- Outcome
- All-cause, CVD and kidney disease mortality
Methodological detailscross-population, two cohorts (US NHANES and UK Biobank)
- Cross-population
- Two cohorts (US NHANES and UK Biobank)
Main finding
As reported in the abstract
Mortality, US NHANES (1442 deaths)
Each group vs lowest quartileEstimate (95% CI)
Highest quartile
adjusted HR, all-cause mortality 0.62(0.50–0.78)
Highest quartile
adjusted HR, CVD mortality 0.54(0.37–0.80)
Highest quartile
adjusted HR, kidney disease mortality 0.22(0.06–0.82)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Mortality, UK Biobank (651 deaths)Highest quartilevs Lowest quartile | adjusted HR, all-cause mortality 0.71 (95% CI 0.57–0.88) | |
| Mortality, UK Biobank (651 deaths)Highest quartilevs Lowest quartile | adjusted HR, CVD mortality 0.65 (95% CI 0.43–0.98) | |
| 0.512Ratio (log scale) |
Dose-response (restricted cubic splines)
- Significant non-linear L-shaped relationship with all-cause mortality in both cohorts and cardiovascular disease (CVD) mortality in the UK cohort
- all p for non-linearity <0.05
Original publication
Higher dietary magnesium intake and lower risks of all‐cause, cardiovascular and kidney disease mortality in diabetes participants: A large cross‐population cohort study. Diabet Med. Published 23 January 2026. doi:10.
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