Association between hemoglobin, albumin, lymphocyte, and platelet score and all-cause and cardiovascular mortality among population with diabetes: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2003–2016
Authors' conclusion
HALP score may serve as a valuable clinical indicator for predicting mortality risk in diabetes patients.
Study context
- Population
- Individuals with diabetes from NHANES 2003–2016, mortality tracked until December 31, 2019
- Participants
- 2,154 individuals
- Exposure
- Highest vs lowest quartile of Hemoglobin, Albumin, Lymphocyte, and Platelets (HALP) score
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 90 months
Methodological detailsNHANES 2003–2016, Cox regression, restricted cubic splines, two-segmented Cox proportional risk model
- NHANES 2003–2016
- Cox regression
- Restricted cubic splines
- Two-segmented Cox proportional risk model
Main finding
As reported in the abstract
Deaths
565
26.23 %
CV deaths
166
7.71 %
Observational data: associations, not effects.
Further findings
Nonlinear relationship (restricted cubic splines (RCS))
- L-shaped relationship; threshold for all-cause mortality
- 49.81
- Threshold for cardiovascular mortality
- 48.78
- HALP scores below thresholds associated with increased mortality
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between hemoglobin, albumin, lymphocyte, and platelet score and all-cause and cardiovascular mortality among population with diabetes: Evidence from the NHANES 2003–2016. Diabetes Res Clin Pract. Published 7 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →