Nonlinear Relationship Between Monocyte‐to‐Lymphocyte Ratio and Bone Mineral Density in Type 2 Diabetes Mellitus: Mediating Role of Fat Distribution
Authors' conclusion
MLR is significantly associated with lumbar spine BMD in T2DM. Higher MLR levels correlated with reduced BMD. VSR plays a significant mediating role in this relationship, highlighting MLR's potential utility in osteoporosis diagnosis and importance of fat management for bone health.
Study context
- Population
- T2D patients over 50 years
- Participants
- 430 participants
- Exposure
- Monocyte-to-lymphocyte ratio (MLR) tertiles
- Outcome
- Association between MLR and lumbar spine BMD
Main finding
As reported in the abstract
Lumbar spine BMD vs MLR
Significant negative correlation between MLR and lumbar spine bone mineral density (BMD), β
−0.701
95%CI −0.112, −0.290
Nonlinear relationship between MLR and BMD; optimal inflection point at MLR
0.1266
Observational data: associations, not effects.
Further findings
VSR and lumbar spine BMD
- VSR negatively correlated with lumbar spine BMD, β
- −0.775 (95%CI: −1.007, −0.504)
Mediation by VSR of MLR–lumbar spine BMD association
- Total effect estimate
- −0.0717
- Direct effect estimate
- −0.0524
- Mediation effect estimate
- −0.0193
- Mediated proportion of total effect
- 26.88%
Original publication
Nonlinear Relationship Between Monocyte‐to‐Lymphocyte Ratio and Bone Mineral Density in Type 2 Diabetes Mellitus: Mediating Role of Fat Distribution. Clin Endocrinol (Oxf). Published 7 May 2025. doi:10.
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