Relationship of neutrophil-to-lymphocyte ratio, in addition to C-reactive protein, with cardiovascular events in patients with type 2 diabetes
Authors' conclusion
In patients with T2D, NLR is related to higher risk of CVD and all-cause mortality, independently from CRP. NLR is related to CVD even when CRP is low, indicating that NLR is a marker of CVD-risk in addition to CRP. Both NLR and CRP are independently related to all-cause mortality in T2D patients.
Study context
- Population
- Patients with T2D from the UCC-SMART cohort
- Participants
- 1,239 patients10,833 person-years
- Exposure
- Neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) with vascular events and all-cause mortality
- Outcome
- Vascular events (cerebrovascular events, MI and vascular death) and all-cause mortality
Methodological detailsmultivariable-adjusted Cox regression
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
NLR per SD, adjusted for CRP
Vascular events: HR per SD in NLR
1.27
95% CI 1.11–1.46
All-cause mortality: HR per SD in NLR
1.15
95% CI 1.02–1.30
Events during follow-up: vascular events
232
Events during follow-up: deaths
302
Observational data: associations, not effects.
Further findings
CRP per SD, adjusted for NLR
- Vascular events: HR per SD in CRP (95% CI 0.90-1.19); not associated
- 1.03
- All-cause mortality: HR per SD in CRP
- 1.18 (95% CI 1.04-1.33)
- Adjusted for NLR
NLR and vascular events in patients with CRP < 2 mg/L
- Vascular events: HR per unit NLR
- 1.45 (95% CI 1.19-1.77)
Original publication
Relationship of neutrophil-to-lymphocyte ratio, in addition to C-reactive protein, with cardiovascular events in patients with type 2 diabetes. Diabetes Res Clin Pract. Published 5 June 2024. doi:10.
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