Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes
Main finding · Low CRFResult — go to the resultAdjusted odds ratio 1.45 95% CI 1.24–1.71Authors' conclusion
In a large cohort of adults with type 2 diabetes, the presence of microvascular disease and its burden were independently associated with lower CRF.
Study context
- Population
- Adults with T2D who underwent maximal exercise testing at baseline in Look AHEAD; mean age 58.9 ± 6.7 years, 58.5% women, 66.1% White
- Participants
- 4,766 adults
- Exposure
- Microvascular disease vs no microvascular disease
- Microvascular diseasen = 1,761
- Outcome
- Low CRF, defined by Aerobics Center Longitudinal Study reference standards
- Follow-up
- Baseline
Main finding
Low CRF
Adjusted odds ratio
1.45
95% CI 1.24–1.71
Microvascular diseasevs No microvascular disease
aOR 1.45 (95% CI 1.24–1.71)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Low CRF by burden of microvascular disease3 vascular territoriesvs No microvascular disease | 2.82 (1.36–5.85) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Low cardiorespiratory fitness (CRF) by microvascular complication type
| aOR (95% CI) | ||
|---|---|---|
| Neuropathy | 1.24 (0.99–1.55) | |
| Retinopathy | 1.34 (1.02–1.76) | |
| DKD | 1.44 (1.20–1.73) | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | No microvascular disease | P value |
|---|---|---|
| CRF (adjusted MET), microvascular disease in 3 territories vs noneLower CRF with 3 territories · adjusted | mean 7.26 MET | P = 0.001 |
- CRF (adjusted MET), microvascular disease in 3 territories vs none: 3 vascular territories mean 6.58 MET
Low CRF by burden of microvascular disease
- Increasing burden of microvascular disease associated with higher odds of low CRF
Original publication
Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes. Diabetes Care. Published 5 June 2024. doi:10.
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