Impact of individual microvascular disease on the risks of macrovascular complications in type 2 diabetes: a nationwide population-based cohort study
Authors' conclusion
T2D patients with microvascular disease have a significantly higher risk of cardiovascular morbidities and mortality than those without microvascular disease. In the matched cohorts, diabetic neuropathy was significantly associated with stroke development, and diabetic retinopathy had a significant association with heart failure compared to other microvascular diseases.
Study context
- Population
- Newly diagnosed T2D patients, National Health Insurance Research Database, Taiwan, 2008–2019matched cohorts
- Exposure
- T2D with vs without microvascular disease; and between matched patients with DKD, DR or neuropathy
- Outcome
- Cardiovascular morbidity and mortality
Methodological detailsnationwide, propensity-score matched
- Nationwide
- Propensity-score matched
Main finding
As reported in the abstract
- Significantly higher risk of cardiovascular morbidities and mortality with microvascular disease vs without
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Stroke development (matched cohorts)DRvs DKDMatched cohorts | 1.11 (1.03–1.2) | |
| Stroke development (matched cohorts)Diabetic neuropathyvs DKDMatched cohorts | 1.17 (1.1–1.25) | |
| Stroke development (matched cohorts)Diabetic neuropathyvs DRMatched cohorts | 1.12 (1.03–1.21) | |
| Incident HF (matched cohorts)DRvs DKDMatched cohorts | 1.43 (1.3–1.57) | |
| Incident HF (matched cohorts)Diabetic neuropathyvs DRMatched cohorts | 0.79 (0.71–0.87) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Impact of individual microvascular disease on the risks of macrovascular complications in type 2 diabetes: a nationwide population-based cohort study. Cardiovasc Diabetol. Published 9 May 2023. doi:10.
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