Microvascular disease and its association with dementia in patients with type 2 diabetes: A nationwide cohort study in Taiwan
Main finding · All-cause dementiaResult — go to the resultAdjusted hazard ratio 1.13 95% CI 1.09–1.17Authors' conclusion
This nationwide cohort study showed that patients with T2D and microvascular disease, particularly diabetic kidney disease and diabetic neuropathy, were associated with a significantly higher risk of Alzheimer's disease, vascular dementia, other dementia and all-cause dementia than those without microvascular disease.
Study context
- Population
- Individuals newly diagnosed with T2D, 1 January 2009 through 31 December 2014, National Health Insurance Research Database, Taiwan
- Exposure
- T2D with vs without microvascular disease
- Outcome
- All-cause dementia
Methodological detailsmatched, multivariable Cox proportional hazard models
- Matched
- Multivariable Cox proportional hazard models
Main finding
As reported in the abstract
Adjusted hazard ratio
1.13
95% CI 1.09–1.17
Microvascular diseasevs Without microvascular disease
aHR 1.13 (95% CI 1.09–1.17)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Alzheimer's disease, by DKD and diabetic neuropathyDKDvs Without microvascular disease | 1.16 (1.02–1.32) | |
| Alzheimer's disease, by DKD and diabetic neuropathyDiabetic neuropathyvs Without microvascular disease | 1.14 (1.03–1.27) | |
| Vascular dementia, by DKD and diabetic neuropathyDKDvs Without microvascular disease | 1.21 (1.06–1.38) | |
| Vascular dementia, by DKD and diabetic neuropathyDiabetic neuropathyvs Without microvascular disease | 1.14 (1.02–1.28) | |
| Other dementia, by DKD and diabetic neuropathyDKDvs Without microvascular disease | 1.11 (1.04–1.19) | |
| Other dementia, by DKD and diabetic neuropathyDiabetic neuropathyvs Without microvascular disease | 1.10 (1.04–1.16) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Microvascular disease and its association with dementia in patients with type 2 diabetes: A nationwide cohort study in Taiwan. Diabetes Obes Metab. Published 29 August 2024. doi:10.
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