Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes
Main finding · Incident CKDResult — go to the resultHazard ratio 0.90 95% CI 0.83–0.97Authors' conclusion
Our findings advocate the beneficial role of fish oil use in preventing CKD among patients with diabetes, which may be mediated by serum levels of HbA1c, CRP and HDL-C, and support public health policies aiming to promote fish oil supplementation for the prevention of diabetes complications.
Study context
- Population
- Patients with diabetes from the UK Biobank3,533 chronic kidney disease (CKD) cases
- Participants
- 24,497 patients
- Exposure
- Fish oil supplement use vs non-use
- Fish oil usersn = 7,122
- Outcome
- Incident CKD
- Follow-up
- Mean of 11.3 years
Methodological detailsUK Biobank, Cox proportional hazards regression, fully adjusted model, mediation analysis
- UK Biobank
- Cox proportional hazards regression
- Fully adjusted model
- Mediation analysis
Main finding
As reported in the abstract
mean 11.3 years follow-up
Hazard ratio
0.90
95% CI 0.83–0.97
Fish oil usersvs Non-users
HR 0.90 (95% CI 0.83–0.97)
Observational data: associations, not effects.
Further findings
Mediation of fish oil–CKD association by serum biomarkers
- Mediated by HbA1c
- 4.7%
- Mediated by C-reactive protein (CRP)
- 3.4%
- Mediated by high-density lipoprotein cholesterol (HDL-C)
- 2.3%
Rate advancement period for CKD
- CKD risk delayed in fish oil users vs non-users by approximately
- 2.79 years
Original publication
Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes. Diabetes Obes Metab. Published 27 August 2024. doi:10.
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