Association of glycaemic control with intraocular pressure in a large general population: Results from the UK Biobank
Authors' conclusion
Impaired glycaemic control was associated with elevated IOP and a possible risk of ocular hypertension among participants with diabetes but of normal ocular health.
Study context
- Population
- UK Biobank participants without eye conditions that may affect intraocular pressure (IOP); mean age 56.7 years, 46.5% male; 6.1% with diabetes
- Participants
- 68,806 participants
- Exposure
- HbA1c and random serum glucose vs IOP
- Outcome
- IOPg and IOPcc (ocular response analyser); ocular hypertension = left-eye IOPg or IOPcc > 21 mmHg
Methodological detailspopulation-based, UK Biobank, multivariate restricted cubic spline and linear regression
- Population-based
- UK Biobank
- Multivariate restricted cubic spline and linear regression
Main finding
As reported in the abstract
Association of HbA1c with IOP in participants with diabetes, per 10-mmol/mol increase in HbA1c (adjusted)
IOPg increase (mmHg), 95% CI 0.12, 0.28
0.20
IOPcc increase (mmHg), 95% CI 0.07, 0.23
0.15
Odds of ocular hypertension increased
6%
95% CI 1.00, 1.13
Observational data: associations, not effects.
Further findings
IOP and ocular hypertension in the whole cohort
- IOPg, mean (SD) 3.6, mmHg
- 15.7
- IOPcc, mean (SD) 3.6, mmHg
- 15.9
- Ocular hypertension, n (11.7%)
- 8055
- Those with diabetes had higher IOP and a higher prevalence of ocular hypertension
Serum glucose and IOP
- Borderline positive association between serum glucose and IOP only in participants without diabetes
Original publication
Association of glycaemic control with intraocular pressure in a large general population: Results from the UK Biobank. Diabetes Obes Metab. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →