Rate and risk factors of kidney function decline among South Asians with type 2 diabetes: analysis of the CARRS Trial
Authors' conclusion
People with diabetes receiving care at urban diabetes clinics in South Asia experienced annual eGFR decline at two times higher rate than that reported from other contemporary international diabetes cohorts. Risk factors for faster decline were similar to those previously established, and thus care delivery models must put an additional emphasis on kidney protective therapies among subgroups with microvascular and macrovascular diabetes complications.
Study context
- Population
- People with T2D at 10 diabetes clinics in India and Pakistan; mean age 54.2 years, median diabetes duration 7.0 years (IQR 3.0–12.0), median CKD-EPI estimated glomerular filtration rate (eGFR) 83.6 (IQR 67.7 to 97.9) mL/min/1.73 m²
- Participants
- 1,146 people
- Primary endpoint
- Rate of eGFR decline (eGFR slope) and its predictors
- Follow-up
- 2.5 years
Methodological detailsmulticentre, linear mixed models, adjusted for randomization and site
- Multicentre
- Linear mixed models
- Adjusted for randomization and site
Primary result
As reported in the abstract
Overall mean eGFR slope
−1.33/mL/min/1.73 m²/year
Pre-existing DR: slope difference (95% CI −3.45 to −0.77), faster eGFR decline
−2.11
Previous CVD: slope difference (95% CI −3.45 to −0.40), faster eGFR decline
−1.93
Statin use: slope difference (95% CI −1.65 to −0.10), faster eGFR decline
−0.87
Further findings
eGFR slope by treatment assignment
- No differences in eGFR slope, intervention vs usual care
Original publication
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