Association of major candidate protein biomarkers and long-term diabetic kidney disease progression among Asians with young-onset type 2 diabetes mellitus
Authors' conclusion
Among seven major candidate proteins, pTNF-R1, partially mediated through hyperglycemia and albuminuria, robustly predicted DKD progression among Asians with young-onset T2DM.
Study context
- Population
- Asians with young-onset T2D (onset ≤ 40 years old)
- Participants
- 824 participants
- Exposure
- Seven candidate protein biomarkers and diabetic kidney disease (DKD) progression
- Outcome
- DKD progression: yearly estimated glomerular filtration rate (eGFR) decline of >3 ml/min/1.73 m² or >40 % from baseline
- Follow-up
- 5.7 years
Main finding
As reported in the abstract
DKD progression
DKD progressors
25.2 %
pTNF-R1 and DKD progression, adjusted for clinical covariates: OR
1.84
95 %CI 1.44–2.34p < 0.001
Observational data: associations, not effects.
Further findings
Mediation of pTNF-R1 effects
%
- Mediated through hyperglycemia
- 8
- Mediated through albuminuria
- 10
AUC of ROC for predicting DKD progression, clinical model with vs without pTNF-R1
- Clinical model AUC
- 0.72 (95 %CI 0.68-0.76)
- Clinical model + pTNF-R1 AUC
- 0.74 (95 %CI 0.70-0.78)
- Improvement in AUC (p = 0.099)
- 0.02
Original publication
Association of major candidate protein biomarkers and long-term diabetic kidney disease progression among Asians with young-onset type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 13 August 2024. doi:10.
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