The potential of cardiac biomarkers, NT-ProBNP and troponin T, in predicting the progression of nephropathy in diabetic patients: A meta‐analysis of prospective cohort studies
Authors' conclusion
The increased blood levels of TnT and NT-proBNP can be considered as predictors of DN progression in diabetic individuals.
Study context
- Population
- Diabetic patients; PubMed, Scopus and Web of Science searched until June 202214 and 9 cohorts
- Participants
- 8,741 vs 7,292
- Comparison
- Higher vs lower NT-proBNP and troponin T (TnT) levels
- NT-proBNPn = 8,741
- TnTn = 7,292
- Outcome
- Progression of DN: eGFR decline, albuminuria, end-stage renal disease or mortality
Methodological detailsrandom-effect models, subgroup analyses, sensitivity analysis, trim and fill analysis
- Random-effect models
- Subgroup analyses
- Sensitivity analysis
- Trim and fill analysis
Pooled result
As reported in the abstract
DN progression
Relative risk (95% CI)
Higher NT-proBNP
1.67(1.44–1.92)
Elevated TnT
1.57(1.34–1.83)
Further pooled results
Diabetic nephropathy (DN) progression, trim and fill analysis (publication bias indicated for both biomarkers)
| RR (95% CI) | ||
|---|---|---|
| NT-proBNP | 1.50 (1.31–1.79) | |
| TnT | 1.35 (1.15–1.60) | |
| 0.512Relative risk (log scale) |
Original publication
The potential of cardiac biomarkers, NT-ProBNP and troponin T, in predicting the progression of nephropathy in diabetic patients: A meta‐analysis of prospective cohort studies. Diabetes Res Clin Pract. Published 9 September 2023. doi:10.
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