Prognostic significance of stress hyperglycemia ratio in patients undergoing percutaneous coronary intervention: a dose–response meta-analysis
Authors' conclusion
Elevated SHR was associated with an increased risk of adverse outcomes after PCI. The dose-response analysis suggested an approximately linear dose-response pattern between SHR and MACCE.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) with stress hyperglycemia ratio (SHR) measured prior to PCI; PubMed, Embase, Cochrane Library, Web of Science, Scopus and ClinicalTrials.gov searched to August 5, 2025
- Participants
- 41,096 patients13 studies
- Comparison
- Elevated vs lower stress hyperglycemia ratio
- Outcome
- Clinical outcomes after PCI by SHR
Methodological detailsROBINS-I risk of bias, GRADE certainty of evidence, sensitivity analyses, Most studies observational; SHR definitions varied; residual confounding cannot be excluded
- ROBINS-I risk of bias
- GRADE certainty of evidence
- Sensitivity analyses
- Most studies observational; SHR definitions varied; residual confounding cannot be excluded
Pooled result
As reported in the abstract
- Elevated SHR associated with increased risks of all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE), cardiovascular mortality, recurrent MI and stroke
- Elevated SHR not associated with repeat revascularization
- Approximately linear dose-response pattern between SHR and MACCE
Further pooled results
- Sensitivity analyses yielded consistent results
Original publication
Prognostic significance of stress hyperglycemia ratio in patients undergoing percutaneous coronary intervention: a dose–response meta-analysis. BMJ Open Diabetes Res Care. Published 31 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →