Renal outcomes following fundus fluorescein angiography in patients with diabetic nephropathy: Incidence, risk factors and three‐month kidney function changes
Authors' conclusion
FFA is associated with a clinically meaningful risk of CA-AKI in patients with advanced DN, particularly in those with eGFR ≤32 mL/min/1.73 m2 and concurrent diuretic therapy.
Study context
- Population
- Patients with diabetic nephropathy (DN) undergoing fundus fluorescein angiography (FFA)
- Participants
- 307 patients
- Outcome
- Incidence of contrast-associated acute kidney injury (CA-AKI): serum creatinine increase ≥0.3 mg/dL within 48 h or ≥1.5-fold within 7 days after FFA
- Follow-up
- Within 7 days after FFA
Main finding
As reported in the abstract
CA-AKI
Contrast-associated acute kidney injury (CA-AKI) incidence
5.2%
Observational data: associations, not effects.
Further findings
Predictors of CA-AKI (multivariate logistic regression)
- ROC-derived baseline eGFR threshold for increased CA-AKI risk
- ≤32 mL/min/1.73 m²
- Lower baseline eGFR and diuretic use were independent predictors of CA-AKI
- Combined model (eGFR + diuretic use) had superior predictive accuracy
- SGLT2i use associated with CA-AKI in univariate analysis but not independently significant after adjustment
Persistent eGFR decline at 3 months among patients with CA-AKI
- Patients with CA-AKI with persistent eGFR decline
- 13 of 16 (81.3%)
- CA-AKI was the strongest predictor of subsequent renal function deterioration
Original publication
Renal outcomes following fundus fluorescein angiography in patients with diabetic nephropathy: Incidence, risk factors and three‐month kidney function changes. Diabet Med. Published 27 August 2026. doi:10.
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