The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us
Authors' conclusion
Better CVH was significantly associated with a lower risk of MCI in people with diabetes, accounting for genetic risk. The association between CVH and MCI and dementia was stronger among individuals with low or moderate genetic risk and appeared attenuated among those with high genetic risk.
Study context
- Population
- People with diabetes without dementia, UK Biobank and All of Us; genetic risk by APOE ε4 alleles and polygenic risk scores (PRS) for Alzheimer diseaseUK Biobank (UKB) 41,374
- Exposure
- Moderate or high cardiovascular health (CVH) vs low CVH
- Outcome
- Risk of mild cognitive impairment (MCI) and dementia
- Follow-up
- Over 15 years (UKB)
Methodological detailstwo cohorts (UK Biobank and All of Us), Cox regression, interaction testing on multiplicative and additive scales
- Two cohorts (UK Biobank and All of Us)
- Cox regression
- Interaction testing on multiplicative and additive scales
Main finding
As reported in the abstract
15 years of follow-up
Moderate or high CVH vs Low CVHHazard ratio (95% CI)P value
MCI
0.82(0.71–0.95)
P < 0.05All-cause dementia
0.97(0.84–1.11)
P = 0.63Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| MCI in participants at high genetic risk (high PRS) | 0.78 (0.62–0.98) | P for additive interaction < 0.05 | |
| 0.512Hazard ratio (log scale) |
All of Us replication
- All of Us (AoU) results were consistent
Original publication
The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us. Diabetes Care. Published 27 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →