Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study
An erratum to this article was published (Diabetes Obes Metab, Sep 2024 ↗)
Authors' conclusion
Higher LE8 scores were associated with a lower risk of incident macrovascular and microvascular complications among individuals with T2D. These findings underscore the significance of adopting fundamental strategies to maintain optimal cardiovascular health and curtail the risk of developing diabetic vascular complications.
Study context
- Population
- Adults with T2D free of macrovascular diseases (CVD and peripheral artery disease) and microvascular complications at baseline, UK Biobank
- Participants
- 11,033 adults
- Exposure
- Highest vs lowest quartile of LE8 score
- Outcome
- Incident macrovascular diseases and microvascular complications
- Follow-up
- Median 12.1 years
Main finding
As reported in the abstract
Highest vs LowestHazard ratio (95% CI)
Incident macrovascular diseases
0.55(0.47–0.62)
Incident microvascular complications
0.61(0.53–0.70)
- Incident macrovascular disease cases
- 1975
- Incident microvascular complication cases
- 1797
- Lower risk of macrovascular diseases per 10-point increase in LE8 score
- 18%
- Lower risk of microvascular complications per 10-point increase in LE8 score
- 15%
Observational data: associations, not effects.
Original publication
Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study. Diabetes Obes Metab. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →