Associations of Life’s Essential 8 cardiovascular health score with prevalent microvascular complications stratified by sex and menopausal status in Chinese adults with type 2 diabetes: a cross-sectional study
Main finding · Prevalent microvascular complicationsResult — go to the resultAdjusted prevalence OR 0.43 95% CI 0.36–0.52Authors' conclusion
Higher LE8 scores are inversely associated with prevalent microvascular complications in Chinese adults with T2DM. The inverse association appeared strongest in premenopausal women.
Study context
- Population
- Chinese adults with T2D in the Metabolic Management Center (MMC) registry; 2894 men (63.9%), 557 premenopausal women (12.3%), 1076 postmenopausal women (23.8%)
- Participants
- 4,527 adults
- Exposure
- High vs moderate vs low LE8 cardiovascular health score
- Outcome
- Prevalent composite microvascular complications:
- DKD
- DR
- DPN
Methodological detailsregistry-based, multivariable logistic regression, restricted cubic spline analyses
- Registry-based
- Multivariable logistic regression
- Restricted cubic spline analyses
Main finding
Prevalent microvascular complications
Adjusted prevalence OR
0.43
95% CI 0.36–0.52
High LE8vs Low LE8
adjusted prevalence OR 0.43 (95% CI 0.36–0.52)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Prevalent microvascular complications by sex and menopausal statusHigh LE8 (premenopausal women)vs Low LE8 (premenopausal women) | 0.17 (0.09–0.33) | |
| 0.050.21520Odds ratio (log scale) |
- Prevalent microvascular complications by sex and menopausal status — Inverse association differed by sex and menopausal status, strongest in premenopausal women
- p for interaction=0.027
Prevalent microvascular complications by sex and menopausal status
- Restricted cubic spline (RCS) curves showed broadly similar inverse associations across groups
Original publication
Associations of Life’s Essential 8 cardiovascular health score with prevalent microvascular complications stratified by sex and menopausal status in Chinese adults with type 2 diabetes: a cross-sectional study. BMJ Open Diabetes Res Care. Published 23 September 2026. doi:10.
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