Sex Differences in “Life’s Essential 8” Cardiovascular Health and Type 2 Diabetes Mellitus Risk Across Menopause Stages
Authors' conclusion
As CVH improved, the reduction in AR for T2DM was more prominent in men than in women. HR trends for CVH and T2DM were similar in men and postmenopausal women. Increased CVH delayed the onset of T2MD both in men and women, with the most significant delay observed in postmenopausal women.
Study context
- Population
- Participants without preexisting T2D from the UK Biobank; Cardiovascular health (CVH) assessed using Life's Essential 8 (LE8)4,315 T2D cases
- Participants
- 126,818 participants
- Exposure
- Higher vs lower CVH in men and in women at different menopausal stages
- Outcome
- Incident T2D (absolute risk and HR per 1-point increase in CVH)
- Follow-up
- Mean 168 months
Methodological detailsUK Biobank, accelerated failure time model
- UK Biobank
- Accelerated failure time model
Main finding
As reported in the abstract
T2D risk per 1-point increase in CVH
Decrease in AR
Decrease in HR
Observational data: associations, not effects.
Further findings
Adjusted median time to T2D onset delay, highest vs lowest CVH quintile
Original publication
Sex Differences in “Life’s Essential 8” Cardiovascular Health and Type 2 Diabetes Mellitus Risk Across Menopause Stages. J Clin Endocrinol Metab. Published 16 August 2024. doi:10.
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