Periodontal tissue susceptibility to glycaemic control in type 2 diabetes
Authors' conclusion
Glycaemic control treatment can effectively improve periodontitis in patients with type 2 diabetes, even in the absence of specific periodontal treatments. However, the periodontal responsiveness to glycaemic control treatment depends on the systemic condition of the patient.
Study context
- Population
- Hospitalized patients with T2D receiving a 2-week intensive glycaemic control regimen
- Participants
- 29 patients
- Exposure
- Before vs after 2-week intensive glycaemic control
- Outcome
- Direct effect of intensive glycaemic control on periodontal tissues (systemic and oral disease indicators before and after treatment)
- Follow-up
- 2 weeks
Methodological detailsbefore–after comparison, inpatient
- Before–after comparison
- Inpatient
Main finding
As reported in the abstract
Glycaemic and periodontal parameters (glycated albumin, PISA) · after 2-week treatment
- Significant reduction in glycaemic and periodontal parameters, incl. glycated albumin and periodontal inflamed surface area (PISA), after treatment
Observational data: associations, not effects.
Further findings
Change in PISA per tooth
- Bimodal distribution of change in PISA per tooth; patients divided into two groups
- In PISA-improved, change in PISA per tooth correlated with FPG, acetoacetic acid and beta-hydroxybutyrate levels
Pretreatment systemic indicators by PISA response · before treatment
- Significantly lower C-peptide, coefficient of variation of R-R interval and ankle-brachial pressure index in PISA non-improved
Original publication
Periodontal tissue susceptibility to glycaemic control in type 2 diabetes. Diabetes Obes Metab. Published 14 August 2024. doi:10.
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