Efficacy and safety of basal‐first titration order in individuals with type 2 diabetes receiving short‐term intensive insulin therapy: An exploratory analysis of BEYOND V
Authors' conclusion
Titrating basal insulin first is an effective and safe method of SIIT in individuals with T2D, rapidly achieving target glucose levels with a relatively low rate of hypoglycaemia.
Study context
- Population
- Hospitalized Chinese adults with uncontrolled T2D, oral therapies withdrawn (except metformin); mean 54.2 years, 59.2% malesentered run-in
- Participants
- 397 adults
- Primary endpoint
- Proportions achieving FBG and 2-hour PBG targets (key outcomes)
- Follow-up
- End of SIIT
Methodological detailssingle-group, run-in period (7- to 10-day), inpatient
- Single-group
- Run-in period (7- to 10-day)
- Inpatient
Primary result
As reported in the abstract
FBG and 2-hour PBG targets achieved
Both fasting blood glucose (FBG) <7.0 mmol/L (<126 mg/dL) and 2-hour postprandial blood glucose (PBG) <10 mmol/L (<180 mg/dL)
374 of 396
94.4%
Both FBG <6.1 mmol/L (<100 mg/dL) and 2-hour PBG <10 mmol/L
282 of 396
71.2%
Further findings
Mean first time to achieve target
Days
- FBG <7 mmol/L
- 4.35
- 2-hour PBG <10 mmol/L
- 3.88
- Both
- 5.04
Safety
Hypoglycaemia · 7- to 10-day run-in (SIIT)
- Hypoglycaemia
- 99 participants (24.9%)
- There was no severe hypoglycaemia
Original publication
Efficacy and safety of basal‐first titration order in individuals with type 2 diabetes receiving short‐term intensive insulin therapy: An exploratory analysis of BEYOND V. Diabetes Obes Metab. Published 19 January 2023. doi:10.
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